Our laboratory has solved a comprehensive set of crystal structure of this large protein family offering the opportunity to understand molecular mechanisms of their regulation and developing new strategies for their selective targeting. A second research focus is on protein kinases. This effort generated several highly selective chemical probes targeting bromodomains. We are particularly interested in protein interactions module of the bromodomain family that specifically recognize ε-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks. As a basis for this work we have generated a comprehensive set of high resolution crystal structures that cover most members of the protein family of interest. My laboratory is interested in understanding molecular mechanisms that regulate protein function of key signalling molecules and how these mechanisms can be utilized for the development of highly selective and potent inhibitors (chemical probes). His research interests are the rational design of selective inhibitors that target protein kinases as well as protein interactions modules that function as reader domains of the epigenetic code. Since 2017 he is the CSO of the newly founded SGC node at the Goethe-University Frankfurt. He remains associated to the SGC as a visiting Professor at Oxford and he is also adjunct Professor of the George Washington University. He joined Frankfurt University (Germany) in 2015 as a Professor of Pharmaceutical Chemistry and the Buchmann Institute of Molecular Life Sciences. From 2008 to 2015 he was a Professor of Structural Biology at the Nuffield Department of Clinical Medicine (NDM) at Oxford University (UK) and between 20 he was the Director for Chemical Biology at the Target Discovery Institute (TDI). He left the company in 2004 to set up a research group at the Structural Genomics Consortium at Oxford University (SGC). In 1999, he joined the Pharmacia Corporation as a principal research scientist in structural biology and biophysics. He did his PhD in protein crystallography at the Karolinska Institute in Stockholm (Sweden) (1996) and continued his career at the Karolinska Institute as a postdoctoral scientist (1996-1999). Prof Stefan Knapp studied Chemistry at the University of Marburg (Germany) and at the University of Illinois (USA).
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